An Overview of Glial Tumours

 Introduction

Tata Memorial Hospital Neuro-Oncology data 2006

Etiology

Classification

Clinical Features

Imaging

Immuno-cytochemistry

Staging & Grading

Natural History of Astrocytomas

Prognostication

Oligodendroglioma

Ependymoma

Prognosis

Supportive Treatment

 

Incidence:

§ Brain tumors are considered rare tumours.

§ But, it is the most common solid tumor of childhood.

Recently we have analyzed the Neuro-Oncology registration data of 2006. Tata Memorial Hospital is a tertiary referral hospital and patients are referred from different parts of India. Thus, TMH neuro-oncology registration data provides important informations regarding brain tumour in India.

TMH Neuro-Oncology registration data 2006:

 

Table #1

TMH Neuro-oncology data 2006

Total No. of cases

656

Male

402 (61.3%)

Female

254 (38.7%)

 

Table # 2

Age distribution

Age

No. of patient

<6 yr

41

7-15 yr

74

16-30 yr

132

31-50 yr

236

51-70 yr

134

>70 yr

13

Table # 3

Distribution of cases according to Sex and Age of presentation

 

< 18 yr

19-40 yr

41-60 yr

>60 yr

 

No. of cases

Male

Female

(n= 159)

(n=258)

(n=175)

(n=48)

Astrocytoma

247 (37.5%)

155 (63%)

92 (37%)

29

94

86

17

Low Grade Glioma

102 (41%)

 57 (59%)

45(41%)

High Grade Glioma

  145 (59%)

 98 (67.5%)

47(28.5%)

Pituitary adenoma

53 (9.4%)

 33 (62%)

20 (38%)

3

28

19

2

Medulloblastoma

43 (6.5%)

 29 (67%)

14 (33%)

31

8

1

0

Ependymoma

43 (6.5%)

 31 (72%)

12 (28%)

17

18

5

1

Brain Metastasis

28 (4.3%)

 13 (46.5%)

15 (53.5%)

0

7

11

9

Craniopharyngioma

24 3.6%)

 16 (66.7%)

08 (33.3%)

11

7

4

1

meningioma

19 (2.9%)

 09 (47.4%)

10 (52.6%)

2

5

8

3

Oligodendroglioma

17 (2.6%)

 13 (76.5%)

04 (23.5%

Brain stem glioma

18 (2.7%)

 13 (72%)

05 (28%)

13

2

3

0

AVM

8 (1.2%)

 04 (50%)

04 (50%)

2

5

1

0

Uncommon brain tumours

29 (4.4%)

 16 (55%)

13 (45%)

16

26

12

11

PNET

11(1.7%)

 07 (63%)

04 (37%

8

3

0

0

Pineal tumour

5 (0.8%)

 03 (60%)

02 (40%)

0

4

1

0

Diagnostic confusion or missing

106 (16%)

 

 

27

51

24

4

Total case : 656

 

Table # 5

Astrocytoma case distribution according to sex and age

Sex

Age (yrs)

No. of cases

Male

Female

<18

19-40

41-60

>60

Pilocytic

27 (11%)

12

15

17

8

1

1

Fibrillary

36 (14.6%)

25

11

3

22

7

4

Anaplastic

50 (20%)

35

15

3

19

25

3

GBM

86 (34.8%)

57

29

2

18

58

8

Gliomas

(no grade ascertained)

48 (19.4%)

26

22

6

14

24

4

Total

247

155

92

 

Table # 6

Brain metastasis

No. of case

28 (4.3%)

Unknown Primary

8

Adenocarcinoma

9

Carcinoma Breast

6

Carcinoma Lung

3

Carcinoma Colon

2

 

Table # 7

Uncommon Brain Tumors

VHL

1

Vasoformative neoplasm

1

Schwanoma

2

Pleomorphic Xanthoastrocytoma

2

Neurofibromatosis

1

Primary CNS Lymphoma

3

Haemangiopericytoma

1

Germinoma

3

Gangioglioma

2

Cordoma

3

Chondrosarcoma

2

Haemangiopericytoma

2

Transitional Cell Carcinoma

1

SEGA

2

DNET

1

 

Table # 4

Site of lesion with Diagnosis at presentation

 

No of cases

Astrocytoma

meningioma

Oligodendroglioma

Ependymoma

PNET

Rightt Tempo-parital region

24

22

0

2

0

1

Right Parital region

7

4

1

0

1

1

Frontal region

40

28

0

6

1

0

Right Fronto-temporal region

3

2

0

0

1

0

Right Fronto-parital region

12

8

0

1

1

0

Post-fossa region

28

10

2

0

4

0

Brain-stem region

19

9

0

0

0

1

Pineal region

6

1

0

0

0

0

Optic chiasmal region

3

3

0

0

0

0

Left Temporal region

14

11

0

1

0

0

left Tempero-parital region

11

10

0

0

0

0

Left Parital region

15

11

1

0

1

0

Left Fronto-parital region

13

10

0

1

0

0

Cervico-dorsal spine

19

4

2

0

8

2

Lumbo-sacral spine

10

3

0

0

5

0

Thallamus/basal ganglia

7

5

0

0

0

0

Fourth Ventricular region

7

3

0

0

4

0

Base of Skull

4

0

1

0

1

0

Corpus callosum

2

2

0

0

0

0

Cranial Nr/5th or 8th

2

0

0

0

0

0

Total valid cases

307

115

9

11

27

6

 

Brain Tumour Foundation Of India
189 B, 1 st Floor, Golden Jubilee Block, 

Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai - 400 012, INDIA
Tel : 91-22-2417 7000, Ext : 4559. Fax : 022-2417 7159 / 2414 6937
Email : btf@braintumourindia.com